Interactions of Oral Molecular Excipients with Breast Cancer Resistance Protein, BCRP
نویسندگان
چکیده
منابع مشابه
Interactions of cyclosporin a with breast cancer resistance protein.
The objective of this study was to investigate whether cyclosporin A (CsA) is a modulator for breast cancer resistance protein (BCRP). The interactions between CsA and BCRP were evaluated by using both membrane- and cell-based assays. CsA inhibited BCRP or BCRP R482T mutant-associated ATPase with an IC(50) of 26.1 and 7.3 microM (31,388 and 8779 ng/ml), respectively, indicating that CsA is a mo...
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ژورنال
عنوان ژورنال: Molecular Pharmaceutics
سال: 2020
ISSN: 1543-8384,1543-8392
DOI: 10.1021/acs.molpharmaceut.9b00658